(RE) began in October 2006 as a quick response to consumer frenzy for red t-shirts by The Gap. The shirts were produced as part of (Product) RED, a cause-marketing product line giving a portion of proceeds to fight AIDS in Africa, and featured a white INSPI(RED) text logo across the front. Following an hour-long Oprah Winfrey Show dedicated to (Product) RED and co-creator Bono, eBay became the only marketplace consumers were able to purchase the red shirts, often at 2 to 3 times the retail price. While The Gap rushed to produce more shirts, (RE) began offering an alternative - red thriftshop t-shirts printed with INSPI(RE)D over any existing logo. EBay searches for the shirts returned results for (RE) shirts in addition to (RED) shirts.

As the 2006 holiday shopping season progressed, (RE) expanded. Consumer demand for (RED) Apple iPods and Motorola RAZR phones inspired COVE(RE)D, encouraging consumers to cover their existing music players and phones with red vinyl. A third response asked consumers to donate to and bid on a growing collection of under-utilized red items auctioned as (RE)SALE.